This domain is found in a group of uncharacterised proteins mainly from actinopterygians that are distantly related and share overall similar domain organisation to the human NEDD4-binding protein 1 (N4BP1). This domain shares a weak sequence similarity to known UBA domains and it is predicted to fold into a typical three helical bundle.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0214","name":"UBA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":231,"pathways":0,"proteins":231,"proteomes":175,"sets":1,"structural_models":{"alphafold":195},"structures":0,"taxa":614},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":59,"alignment:full":158},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}