This domain is found in two tandem copies in the Alpha-glucan water dikinase (GWD1 and GWD2) from Arabidopsis thaliana and related proteins. It is predicted to adopt a globular structure consisting of three helical bundle. GWD1 is involved in the incorporation of phosphate into starch-like alpha-glucan, mostly at the C-6 position of glucose units [[cite:PUB00153995]]. This enzyme acts as regulator of starch mobilization by controlling the phosphate content of starch. The function of the domain represented in this entry is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00153995":{"PMID":11487701,"ISBN":null,"volume":"13","issue":"8","year":2001,"title":"The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter.","URL":null,"raw_pages":"1907-18","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Yu TS","Kofler H","Hausler RE","Hille D","Flugge UI","Zeeman SC","Smith AM","Kossmann J","Lloyd J","Ritte G","Steup M","Lue WL","Chen J","Weber A."],"DOI_URL":"https://doi.org/10.1105/tpc.010091"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":1603,"pathways":0,"proteins":1012,"proteomes":409,"sets":0,"structural_models":{"alphafold":202},"structures":0,"taxa":1119},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":97,"alignment:full":1009},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}