This entry represents a region of unknown function found in proteins from fungi and bacteria. This region is composed of a pair of two flattened, orthogonally packed, beta-barrels that share significant global similarity to members of the AttH-like superfamily. It is likely that this region possesses enzymatic activity.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0970","name":"AttH-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":1330,"pathways":0,"proteins":1329,"proteomes":711,"sets":1,"structural_models":{"alphafold":894},"structures":0,"taxa":1353},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":75,"alignment:full":705},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}