This entry represents a domain found towards the N-terminal of a group of proteins from nematodes such as Trichuris suis and Trichinella britovi, members of the BPI/LBP/Plunc family of proteins which share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP). The exact function of these proteins is unknown, however, according to their structure predictions and homology to CEPT/PLTP, they may be involved in lipid binding.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0648","name":"Aha1_BPI"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":22,"pathways":0,"proteins":21,"proteomes":13,"sets":1,"structural_models":{"alphafold":19},"structures":0,"taxa":28},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":22},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}