{"metadata":{"accession":"PF23168","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055486","hierarchy":null,"name":{"name":"CUL7/CUL9, N-terminal beta-barrel domain","short":"CUL7_CUL9_N"},"description":[{"text":"<p>This domain is found N-terminal in the homologues of human Cullin-7 (CUL7) and Cullin-9 (CUL9). It adopts a beta-barrel structure with some similarity to chromodomains and is known as a small beta-domain (SBD) [[cite:PUB00156050],[cite:PUB00155195]]. In both CUL7 and CUL9, this domain is usually followed by an ARM-like domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155195":{"PMID":38605244,"ISBN":null,"volume":"31","issue":"7","year":2024,"title":"Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.","URL":null,"raw_pages":"1083-1094","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Horn-Ghetko D","Hopf LVM","Tripathi-Giesgen I","Du J","Kostrhon S","Vu DT","Beier V","Steigenberger B","Prabu JR","Stier L","Bruss EM","Mann M","Xiong Y","Schulman BA."],"DOI_URL":"https://doi.org/10.1038/s41594-024-01257-y"},"PUB00156050":{"PMID":35982156,"ISBN":null,"volume":"29","issue":"9","year":2022,"title":"Structure of CRL7<sup>FBXW8</sup> reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.","URL":null,"raw_pages":"854-862","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Hopf LVM","Baek K","Klugel M","von Gronau S","Xiong Y","Schulman BA."],"DOI_URL":"https://doi.org/10.1038/s41594-022-00815-6"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":77,"interactions":0,"matches":1406,"pathways":0,"proteins":1406,"proteomes":574,"sets":0,"structural_models":{"alphafold":347},"structures":4,"taxa":1850},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":1161},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}