This domain is found in a group of uncharacterised plant proteins. These proteins are probably distantly related to the plant-specific actin-binding protein SCAB1 and are predicted to contain a fusion domain composed of Ig and PH-like domains in a similar arrangement as in SCAB1 (([pfam:PF16709]) and ([pfam:PF17684])) [[cite:PUB00076164]]. The domain represented by this entry corresponds to an atypical PH-like domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00076164":{"PMID":22356912,"ISBN":null,"volume":"287","issue":"15","year":2012,"title":"Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain.","URL":null,"raw_pages":"11981-90","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Zhang W","Zhao Y","Guo Y","Ye K."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.338525"}},"set_info":{"accession":"CL0266","name":"PH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":2197,"pathways":0,"proteins":1952,"proteomes":350,"sets":1,"structural_models":{"alphafold":1488},"structures":0,"taxa":983},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":1434},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}