This is a domain of unknown function predominantly found at the N-terminal of sequences from ticks, spiders and similar sequences from arthropods. According to structure predictions this domain may adopt a alpha-helical bundle fold similar to Ty3 transposon capsid-like proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0523","name":"GAG-polyprotein"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":194,"interactions":0,"matches":3709,"pathways":0,"proteins":3700,"proteomes":271,"sets":1,"structural_models":{"alphafold":3101},"structures":0,"taxa":1117},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":2658},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}