{"metadata":{"accession":"PF22997","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054295","hierarchy":null,"name":{"name":"Chitin synthase 4-like domain","short":"CHS4"},"description":[{"text":"<p>This domain is found in a group of fungal proteins, including Chitin synthase 4 from Gibberella zeae (CHS4), which plays a role in the polymerisation of chitin [[cite:PUB00155063],[cite:PUB00155061]]. This domain is predicted to adopt a globular structure with similarity to Cytochrome b5-like heme/steroid binding domain ([pfam:PF00173]). Despite this global similarity this domain lacks haem coordinating residues and is probably not involved in haem binding.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155061":{"PMID":27725723,"ISBN":null,"volume":"6","issue":null,"year":2016,"title":"The chitin synthase FgChs2 and other FgChss co-regulate vegetative development and virulence in F. graminearum.","URL":null,"raw_pages":"34975","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Liu Z","Zhang X","Liu X","Fu C","Han X","Yin Y","Ma Z."],"DOI_URL":"https://doi.org/10.1038/srep34975"},"PUB00155063":{"PMID":10569783,"ISBN":null,"volume":"67","issue":"12","year":1999,"title":"WdChs4p, a homolog of chitin synthase 3 in Saccharomyces cerevisiae, alone cannot support growth of Wangiella (Exophiala) dermatitidis at the temperature of infection.","URL":null,"raw_pages":"6619-30","medline_journal":"Infect Immun","ISO_journal":"Infect Immun","authors":["Wang Z","Zheng L","Hauser M","Becker JM","Szaniszlo PJ."],"DOI_URL":"https://doi.org/10.1128/IAI.67.12.6619-6630.1999"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":62,"interactions":0,"matches":2475,"pathways":0,"proteins":2475,"proteomes":1464,"sets":0,"structural_models":{"alphafold":1582},"structures":0,"taxa":3068},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":287,"alignment:full":2043},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}