This domain of unknown function is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 [[cite:PUB00153916]]. This enzyme plays a central role in histone code. This domain is predicted to adopt an open beta-barrel with an SH3-like topology.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00153916":{"PMID":16603237,"ISBN":null,"volume":"125","issue":"3","year":2006,"title":"JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.","URL":null,"raw_pages":"483-95","medline_journal":"Cell","ISO_journal":"Cell","authors":["Yamane K","Toumazou C","Tsukada Y","Erdjument-Bromage H","Tempst P","Wong J","Zhang Y."],"DOI_URL":"https://doi.org/10.1016/j.cell.2006.03.027"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":1996,"pathways":0,"proteins":1996,"proteomes":685,"sets":1,"structural_models":{"alphafold":214},"structures":0,"taxa":2415},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":54,"alignment:full":1537},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}