{"metadata":{"accession":"PF22984","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055114","hierarchy":null,"name":{"name":"Mediator of RNA polymerase II transcription subunit 14, RM6","short":"RM6_Med14"},"description":[{"text":"<p>This entry represents an alpha/beta motif that is found tandemly repeated in the homologues of human Mediator of RNA polymerase II transcription subunit 14 (Med14). Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Med14 along with Med17 are scaffold subunits in nucleating Mediator [[cite:PUB00154060],[cite:PUB00151584]]. The major portion of Med14 exists in the Head-Shoulder module of the Mediator and consists of nine tandem repeats (RM1 to RM9), which are arranged in an atypical right-handed helix [[cite:PUB00151584]]. This entry represents repeat RM6.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151584":{"PMID":33958484,"ISBN":null,"volume":"372","issue":"6546","year":2021,"title":"Structures of the human Mediator and Mediator-bound preinitiation complex.","URL":null,"raw_pages":"eabg0635","medline_journal":"Science","ISO_journal":"Science","authors":["Chen X","Yin X","Li J","Wu Z","Qi Y","Wang X","Liu W","Xu Y."],"DOI_URL":null},"PUB00154060":{"PMID":31402173,"ISBN":null,"volume":"178","issue":"5","year":2019,"title":"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.","URL":null,"raw_pages":"1145-1158.e20","medline_journal":"Cell","ISO_journal":"Cell","authors":["El Khattabi L","Zhao H","Kalchschmidt J","Young N","Jung S","Van Blerkom P","Kieffer-Kwon P","Kieffer-Kwon KR","Park S","Wang X","Krebs J","Tripathi S","Sakabe N","Sobreira DR","Huang SC","Rao SSP","Pruett N","Chauss D","Sadler E","Lopez A","Nobrega MA","Aiden EL","Asturias FJ","Casellas R."],"DOI_URL":"https://doi.org/10.1016/j.cell.2019.07.011"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":2008,"pathways":0,"proteins":2006,"proteomes":1079,"sets":0,"structural_models":{"alphafold":275,"bfvd":0},"structures":14,"taxa":3746},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":1443},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}