{"metadata":{"accession":"PF22833","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR053899","hierarchy":null,"name":{"name":"C5orf34-like, second domain","short":"C5orf34_2nd"},"description":[{"text":"<p>This entry represents a domain located C-terminal to [pfam:PF15025] in a family of eukaryotic proteins, including the human uncharacterised protein C5orf34, which has been reported to be correlated with an unfavourable prognosis of patients from a variety of human malignancies [[cite:PUB00154384]]. This domain is predicted to show an alpha-beta structure with high structural similarity to a polo box [[cite:PUB00152793]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00154384":{"PMID":38078888,"ISBN":null,"volume":"15","issue":"23","year":2023,"title":"Integration of genomics and transcriptomics highlights the crucial role of chromosome 5 open reading frame 34 in various human malignancies.","URL":null,"raw_pages":"14384-14410","medline_journal":"Aging (Albany NY)","ISO_journal":"Aging (Albany NY)","authors":["Li Y","Zhang Y","Sun D","Zhang X","Long S","Feng J","Wang Z."],"DOI_URL":"https://doi.org/10.18632/aging.205310"},"PUB00152793":{"PMID":36419248,"ISBN":null,"volume":"32","issue":"1","year":2023,"title":"DALI shines a light on remote homologs: One hundred discoveries.","URL":null,"raw_pages":"e4519","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Holm L","Laiho A","Toronen P","Salgado M."],"DOI_URL":"https://doi.org/10.1002/pro.4519"}},"set_info":{"accession":"CL0708","name":"Polo-box"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":650,"pathways":0,"proteins":635,"proteomes":468,"sets":1,"structural_models":{"alphafold":533},"structures":0,"taxa":1675},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":104,"alignment:full":505},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}