{"metadata":{"accession":"PF22758","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054438","hierarchy":null,"name":{"name":"Structural cement protein (E217 gp24/Pam3 gp6)","short":"Phage_cement"},"description":[{"text":"<p>E217 is a Pseudomonas phage used in an experimental cocktail to eradicate cystic fibrosis-associated Pseudomonas aeruginosa. Gp24 is a trimeric structural protein and component of the E217 icosahedral head.Gp24 adopts a beta-tulip fold similar to the gp87 protein found in the thermophilic phage P74-26. Each gp24 subunit consists of two anti-parallel beta-sheets, that form a tulip-like structure. Gp24 structural protein probably stabilises the E217 capsid.  This entry includes the cement protein gp6 of cyanophage Pam3. It consists of an N-terminal beta-tulip domain followed by a C-terminal domain of seven antiparallel beta-strands. Gp6 trimers sit at the icosahedral threefold and quasi-threefold axes, stabilizing the capsid shell.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00154413":{"PMID":36656854,"ISBN":null,"volume":"120","issue":"4","year":2023,"title":"Fine structure and assembly pattern of a minimal myophage Pam3.","URL":null,"raw_pages":"e2213727120","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Yang F","Jiang YL","Zhang JT","Zhu J","Du K","Yu RC","Wei ZL","Kong WW","Cui N","Li WF","Chen Y","Li Q","Zhou CZ."],"DOI_URL":"https://doi.org/10.1073/pnas.2213727120"},"PUB00153918":{"PMID":37422479,"ISBN":null,"volume":"14","issue":"1","year":2023,"title":"High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217.","URL":null,"raw_pages":"4052","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Li F","Hou CD","Lokareddy RK","Yang R","Forti F","Briani F","Cingolani G."],"DOI_URL":"https://doi.org/10.1038/s41467-023-39756-z"}},"set_info":{"accession":"CL0845","name":"Beta_tulip"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":1250,"pathways":0,"proteins":1246,"proteomes":639,"sets":1,"structural_models":{"alphafold":598,"bfvd":15},"structures":6,"taxa":2060},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":161,"alignment:full":368},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}