{"metadata":{"accession":"PF22522","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054267","hierarchy":null,"name":{"name":"Family of unknown function (DUF6998)","short":"DUF6998"},"description":[{"text":"<p>This is a family of uncharacterised bacterial proteins. They share significant sequence similarity with PvuII endonucleases and are predicted to adopt similar structure. The predicted structures, however, do not suggest similarity in the active site architecture.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":509,"pathways":0,"proteins":504,"proteomes":486,"sets":1,"structural_models":{"alphafold":289},"structures":2,"taxa":1108},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":208},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}