{"metadata":{"accession":"PF22479","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054252","hierarchy":null,"name":{"name":"Cyanophage baseplate Pam3 plug gp18","short":"Pam3_gp18"},"description":[{"text":"<p>This family, previously known as DUF6983, represents Cyanophage baseplate Pam3 plug gp18 and related proteins. Gp18 has structural similarity to a component of the baseplate Complex for Myoviridae Phage XM1. The cyanophage Pam3 has a substantially simpler molecular organisation than the prototypical, contractile-tail bacteriophage T4, but it retains the essential elements required for DNA injection. The baseplate of Pam3 contains six protein components: the trimeric spike gp20, the trimeric hub gp19, the baseplate wedge (six heterotriplexes of gp22-gp23), the plug of six gp18 monomers, and the fibers (12 trimers of gp24) [[cite:PUB00154413]]. The plug gp18 consists of two-layered beta-sheets and a C-terminal alpha-helix, resembling the immunoglobin fold. Each plug monomer is embedded between the two C-terminal helices of the tube initiator, forming a 'plug' to fix the core helical bundle of the wedge onto the hub [[cite:PUB00154413]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00154413":{"PMID":36656854,"ISBN":null,"volume":"120","issue":"4","year":2023,"title":"Fine structure and assembly pattern of a minimal myophage Pam3.","URL":null,"raw_pages":"e2213727120","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Yang F","Jiang YL","Zhang JT","Zhu J","Du K","Yu RC","Wei ZL","Kong WW","Cui N","Li WF","Chen Y","Li Q","Zhou CZ."],"DOI_URL":"https://doi.org/10.1073/pnas.2213727120"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":1235,"pathways":0,"proteins":1235,"proteomes":1081,"sets":0,"structural_models":{"alphafold":507},"structures":9,"taxa":2192},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":220,"alignment:full":498},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}