This is a family of uncharacterised proteins. They are predicted to adopt a globular alpha/beta structure consisting of a meander beta-sheet and two helices packed on one side on the sheet. These proteins contain three highly conserved histidines that in the predicted structure cluster close in space and could potentially form a metal binding site.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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