{"metadata":{"accession":"PF22396","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054249","hierarchy":null,"name":{"name":"Family of unknown function (DUF6976)","short":"DUF6976"},"description":[{"text":"<p>This family of uncharacterised proteins is found mainly in Proteobacteria. It is likely to consists of two domains that engage in extensive contacts mainly via hydrophobic residues. The predicted structure of the N-terminal domain has similarity to chorismatases.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":216,"pathways":0,"proteins":216,"proteomes":197,"sets":0,"structural_models":{"alphafold":150},"structures":0,"taxa":486},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":117,"alignment:full":145},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}