This is a domain found in uncharacterised bacterial proteins that is predicted to be helical. It contains a nearly invariant tryptophan toward the N terminus and a highly conserved motif [F/Y]GGMGSx(2)D toward the C-terminus.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":280,"pathways":0,"proteins":280,"proteomes":268,"sets":0,"structural_models":{"alphafold":150},"structures":0,"taxa":597},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":109},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}