This is a family of uncharacterised proteins found in archaea and bacteria. These proteins are predicted to adopt similar structure to the members of SufE/NifU superfamily. They contain three invariant cysteine residues and a fourth semi-conserved residue either cysteine or histidine. These residues are likely to define a potential Zn-binding site similar to the binding site observed in SufU.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0233","name":"SufE_NifU"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":250,"pathways":0,"proteins":250,"proteomes":155,"sets":1,"structural_models":{"alphafold":223},"structures":0,"taxa":382},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":106,"alignment:full":168},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}