This domain is found either as standalone or in combination with other domains in a group of uncharacterised proteins. It is distantly related to EDC3 mRNA-decapping protein 3 and it could be involved in RNA-binding. It is predicted to adopt a barrel-like structure with a typical Sm-like fold. The pair of glycines responsible for maintaining the Sm-barrel curvature are also conserved in the members of this family.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":46,"pathways":0,"proteins":46,"proteomes":37,"sets":1,"structural_models":{"alphafold":31},"structures":0,"taxa":145},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":33},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}