This domain is found in uncharacterised bacterial proteins either standalone or in combination with other domains. It is distantly related to the type II restriction endonucleases with predicted similar active site architecture. These proteins are most likely endonucleases based on the strict conservation of the putative active site residues.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":162,"pathways":0,"proteins":162,"proteomes":150,"sets":1,"structural_models":{"alphafold":104},"structures":0,"taxa":423},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":74,"alignment:full":93},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}