This entry represents a beta propeller domain composed of five blades. It is often found in large extracellular proteins in one or more copies. It is uncertain whether this domain might have an enzymatic function or a ligand binding function. Structurally this domain appears to have a sixfold symmetry, but one of the blades takes up the space of normal repeats. This unusual blade is composed of three strands of the first repeat and a final C-terminal strand from the last repeat.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":297,"interactions":0,"matches":1701,"pathways":0,"proteins":1554,"proteomes":1295,"sets":1,"structural_models":{"alphafold":794},"structures":0,"taxa":2237},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":895},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}