This entry represents a small bacterial protein of unknown function. Its predicted structure shows a 6 stranded beta sheet with a C-terminal helix packed on one side. In a few proteins this domain is associated with [pfam:PF15595] a presumed immunity protein, which could suggest this domain may have a toxin function or be involved in a toxin/antitoxin system or in phage defence.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":367,"pathways":0,"proteins":367,"proteomes":349,"sets":0,"structural_models":{"alphafold":209},"structures":0,"taxa":698},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":173},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}