This entry represents a family of uncharacterised proteins that have a five fold symmetric alpha/beta propeller fold belonging to the GME (guanidino-group modifying enzymes) superfamily [[cite:PUB00009967],[cite:PUB00151878]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00009967":{"PMID":11504612,"ISBN":null,"volume":"26","issue":"8","year":2001,"title":"A novel superfamily of enzymes that catalyze the modification of guanidino groups.","URL":null,"raw_pages":"465-8","medline_journal":"Trends Biochem Sci","ISO_journal":"Trends Biochem. Sci.","authors":["Shirai H","Blundell TL","Mizuguchi K."],"DOI_URL":"http://dx.doi.org/10.1016/S0968-0004(01)01906-5"},"PUB00151878":{"PMID":16779844,"ISBN":null,"volume":"64","issue":"4","year":2006,"title":"The guanidino-group modifying enzymes: structural basis for their diversity and commonality.","URL":null,"raw_pages":"1010-23","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Shirai H","Mokrab Y","Mizuguchi K."],"DOI_URL":null}},"set_info":{"accession":"CL0197","name":"GME"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":386,"pathways":0,"proteins":386,"proteomes":380,"sets":1,"structural_models":{"alphafold":271},"structures":0,"taxa":690},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":113,"alignment:full":250},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}