{"metadata":{"accession":"PF21773","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR049258","hierarchy":null,"name":{"name":"ODAD1 central coiled coil region","short":"ODAD1_CC"},"description":[{"text":"<p>This domain, previously know as DUF6872, is found in Outer dynein arm-docking complex subunit 1 (ODAD1, CCDC114) from humans and similar eukaryotic proteins. In mammals, CCDC114 forms a hetero-coiled coil with ODAD1/CCDC151 within the A07/A08 interprotofilament cleft, analogous to the DC1/2 coiled coil of the trimeric ODA-DC observed in C. reinhardtii axoneme [[cite:PUB00152762],[cite:PUB00100771]]. DC2 is a homolog of the human ODAD1/CCDC151 and in C.reinhardtii it is a part of the ODA-DC that consists of three proteins: DC1, DC2, and DC3. The N-terminal halves of DC1 and DC2 form a microtubule-bound heteromeric coiled-coil [[cite:PUB00152762],[cite:PUB00152763]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00152763":{"PMID":33473120,"ISBN":null,"volume":"12","issue":"1","year":2021,"title":"Structure of a microtubule-bound axonemal dynein.","URL":null,"raw_pages":"477","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Walton T","Wu H","Brown A."],"DOI_URL":"https://doi.org/10.1038/s41467-020-20735-7"},"PUB00152762":{"PMID":31668805,"ISBN":null,"volume":"179","issue":"4","year":2019,"title":"Structure of the Decorated Ciliary Doublet Microtubule.","URL":null,"raw_pages":"909-922.e12","medline_journal":"Cell","ISO_journal":"Cell","authors":["Ma M","Stoyanova M","Rademacher G","Dutcher SK","Brown A","Zhang R."],"DOI_URL":"https://doi.org/10.1016/j.cell.2019.09.030"},"PUB00100771":{"PMID":34715025,"ISBN":null,"volume":"184","issue":"23","year":2021,"title":"De novo identification of mammalian ciliary motility proteins using cryo-EM.","URL":null,"raw_pages":"5791-5806.e19","medline_journal":"Cell","ISO_journal":"Cell","authors":["Gui M","Farley H","Anujan P","Anderson JR","Maxwell DW","Whitchurch JB","Botsch JJ","Qiu T","Meleppattu S","Singh SK","Zhang Q","Thompson J","Lucas JS","Bingle CD","Norris DP","Roy S","Brown A."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":65,"interactions":0,"matches":3740,"pathways":0,"proteins":3489,"proteomes":1307,"sets":0,"structural_models":{"alphafold":3002},"structures":13,"taxa":4258},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":131,"alignment:full":2963},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}