{"metadata":{"accession":"PF21771","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR049270","hierarchy":null,"name":{"name":"CFAP58 central coiled coil","short":"CFAP58_CC"},"description":[{"text":"<p>This domain is found in Cilia- and flagella-associated protein 58 (CFAP58) and related eukaryotic proteins. The human CFAP58 protein has an essential role in the assembly and organisation of the sperm flagellar axoneme [[cite:PUB00151877]]. This domain forms a parallel coiled coil that in the C. reinhardtii axonemal structure lays on the doublet microtubule surface and interacts with the N terminus of the MIA coiled coil [[cite:PUB00152767]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00152767":{"PMID":37258679,"ISBN":null,"volume":"618","issue":"7965","year":2023,"title":"Axonemal structures reveal mechanoregulatory and disease mechanisms.","URL":null,"raw_pages":"625-633","medline_journal":"Nature","ISO_journal":"Nature","authors":["Walton T","Gui M","Velkova S","Fassad MR","Hirst RA","Haarman E","O'Callaghan C","Bottier M","Burgoyne T","Mitchison HM","Brown A."],"DOI_URL":"https://doi.org/10.1038/s41586-023-06140-2"},"PUB00151877":{"PMID":32791035,"ISBN":null,"volume":"107","issue":"3","year":2020,"title":"Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.","URL":null,"raw_pages":"514-526","medline_journal":"Am J Hum Genet","ISO_journal":"Am J Hum Genet","authors":["He X","Liu C","Yang X","Lv M","Ni X","Li Q","Cheng H","Liu W","Tian S","Wu H","Gao Y","Yang C","Tan Q","Cong J","Tang D","Zhang J","Song B","Zhong Y","Li H","Zhi W","Mao X","Fu F","Ge L","Shen Q","Zhang M","Saiyin H","Jin L","Xu Y","Zhou P","Wei Z","Zhang F","Cao Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":1999,"pathways":0,"proteins":1966,"proteomes":1289,"sets":0,"structural_models":{"alphafold":1726},"structures":5,"taxa":4183},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":1838},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}