{"metadata":{"accession":"PF21647","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR049172","hierarchy":null,"name":{"name":"CORD, C-terminal domain","short":"CORD_C"},"description":[{"text":"<p>This domain is found at the C-terminal in Protein CORTICAL MICROTUBULE DISORDERING (CORD) proteins found in plants. This domain may consist of 5-6 alpha-helices. CORD proteins are microtubule-associated proteins that are required, redundantly with CORD2, for the formation of the pitted secondary cell wall of metaxylem vessels [[cite:PUB00163241]]. CORD1 from Arabidopsis thaliana controls the disorganisation of the parallel cortical microtubule network by modulating microtubule attachment to the plasma membrane in metaxylem vessel cells; this mechanism probably relies on disruption of interactions between ARAC10/ROP11 and cortical microtubules [[cite:PUB00163241]5].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00163241":{"PMID":2913346,"ISBN":null,"volume":"141","issue":"2","year":1989,"title":"The management of chronic interstitial cystitis by substitution cystoplasty.","URL":null,"raw_pages":"287-91","medline_journal":"J Urol","ISO_journal":"J Urol","authors":["Webster GD","Maggio MI."],"DOI_URL":"https://doi.org/10.1016/s0022-5347(17)40743-9"},"PUB00163242":{"PMID":29133465,"ISBN":null,"volume":"29","issue":"12","year":2017,"title":"CORTICAL MICROTUBULE DISORDERING1 Is Required for Secondary Cell Wall Patterning in Xylem Vessels.","URL":null,"raw_pages":"3123-3139","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Sasaki T","Fukuda H","Oda Y."],"DOI_URL":"https://doi.org/10.1105/tpc.17.00663"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":83,"interactions":0,"matches":3782,"pathways":0,"proteins":3244,"proteomes":378,"sets":0,"structural_models":{"alphafold":2632},"structures":0,"taxa":1045},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":39,"alignment:full":2550},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}