{"metadata":{"accession":"PF21028","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048342","hierarchy":null,"name":{"name":"Protein of unknown function (DUF1285), C-terminal domain","short":"DUF1285_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of several hypothetical bacterial proteins. The structure revealed a superficial similarity of this domain to pleckstrin homology-like folds [[cite:PUB00062529]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00062529":{"PMID":20944214,"ISBN":null,"volume":"66","issue":"Pt 10","year":2010,"title":"Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.","URL":null,"raw_pages":"1218-25","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Han GW","Bakolitsa C","Miller MD","Kumar A","Carlton D","Najmanovich RJ","Abdubek P","Astakhova T","Axelrod HL","Chen C","Chiu HJ","Clayton T","Das D","Deller MC","Duan L","Ernst D","Feuerhelm J","Grant JC","Grzechnik A","Jaroszewski L","Jin KK","Johnson HA","Klock HE","Knuth MW","Kozbial P","Krishna SS","Marciano D","McMullan D","Morse AT","Nigoghossian E","Okach L","Reyes R","Rife CL","Sefcovic N","Tien HJ","Trame CB","van den Bedem H","Weekes D","Xu Q","Hodgson KO","Wooley J","Elsliger MA","Deacon AM","Godzik A","Lesley SA","Wilson IA."],"DOI_URL":null}},"set_info":{"accession":"CL1010","name":"DUF1285-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":3594,"pathways":0,"proteins":3594,"proteomes":3586,"sets":1,"structural_models":{"alphafold":2300},"structures":1,"taxa":4708},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":1764},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}