"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF21002"	"{'subfamilies': 0, 'domain_architectures': 33, 'interactions': 0, 'matches': 3111, 'pathways': 0, 'proteins': 3105, 'proteomes': 905, 'sets': 0, 'structural_models': {'alphafold': 2906, 'bfvd': 0}, 'structures': 16, 'taxa': 2884}"	"{}"	"[{'text': '<p>This family includes Transmembrane protein 106A/B/C, type II transmembrane proteins which have homology to the late embryogenesis abundant-2 (LEA-2) domain [[cite:PUB00100166]]. TMEM106A has been identified as a key factor to regulate macrophage activation and a tumour suppressor in gastric, renal cancer and non small-cell lung carcinoma (NSCLC) [[cite:PUB00100168],[cite:PUB00100167]]. TMEM106B localises to late endosomes and lysosomes, and it is involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6 [[cite:PUB00070924]]. Its overexpression is associated with familial frontotemporal lobar degeneration [[cite:PUB00100169]]. It has also been identified as a protein required for productive SARS-CoV-2 [[cite:PUB00100166]]. Structural analysis of LEA-2 domains revealed that they have a long, conserved lipid-binding groove, implying that TMEM106B and its homologues Vac7 and Tag1 from yeast, may all be lipid transfer  proteins in the lumen of late endocytic organelles [[cite:PUB00100166]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR048511"	False	False	False	"{'PUB00100167': {'PMID': 29131025, 'ISBN': None, 'volume': '42', 'issue': '5', 'year': 2017, 'title': 'TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer.', 'URL': None, 'raw_pages': '853-864', 'medline_journal': 'Kidney Blood Press Res', 'ISO_journal': 'Kidney Blood Press Res', 'authors': ['Wu C', 'Xu J', 'Wang H', 'Zhang J', 'Zhong J', 'Zou X', 'Chen Y', 'Yang G', 'Zhong Y', 'Lai D', 'Li X', 'Tang A.'], 'DOI_URL': None}, 'PUB00100166': {'PMID': 34347309, 'ISBN': None, 'volume': '90', 'issue': '1', 'year': 2022, 'title': 'TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.', 'URL': None, 'raw_pages': '164-175', 'medline_journal': 'Proteins', 'ISO_journal': 'Proteins', 'authors': ['Levine TP.'], 'DOI_URL': None}, 'PUB00070924': {'PMID': 24357581, 'ISBN': None, 'volume': '33', 'issue': '5', 'year': 2014, 'title': 'The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.', 'URL': None, 'raw_pages': '450-67', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Schwenk BM', 'Lang CM', 'Hogl S', 'Tahirovic S', 'Orozco D', 'Rentzsch K', 'Lichtenthaler SF', 'Hoogenraad CC', 'Capell A', 'Haass C', 'Edbauer D.'], 'DOI_URL': 'http://dx.doi.org/10.1002/embj.201385857'}, 'PUB00100168': {'PMID': 30456879, 'ISBN': None, 'volume': None, 'issue': None, 'year': 2018, 'title': 'TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells.', 'URL': None, 'raw_pages': None, 'medline_journal': 'J Cell Biochem', 'ISO_journal': 'J Cell Biochem', 'authors': ['Liu J', 'Zhu H.'], 'DOI_URL': None}, 'PUB00100169': {'PMID': 23136129, 'ISBN': None, 'volume': '22', 'issue': '4', 'year': 2013, 'title': 'The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.', 'URL': None, 'raw_pages': '685-95', 'medline_journal': 'Hum Mol Genet', 'ISO_journal': 'Hum Mol Genet', 'authors': ['Brady OA', 'Zheng Y', 'Murphy K', 'Huang M', 'Hu F.'], 'DOI_URL': None}}"	""	"{'name': 'Transmembrane protein 106 N-terminal region', 'short': 'TMEM106_N'}"	""	""	""	"pfam"	"family"	""