{"metadata":{"accession":"PF21002","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048511","hierarchy":null,"name":{"name":"Transmembrane protein 106 N-terminal region","short":"TMEM106_N"},"description":[{"text":"<p>This family includes Transmembrane protein 106A/B/C, type II transmembrane proteins which have homology to the late embryogenesis abundant-2 (LEA-2) domain [[cite:PUB00100166]]. TMEM106A has been identified as a key factor to regulate macrophage activation and a tumour suppressor in gastric, renal cancer and non small-cell lung carcinoma (NSCLC) [[cite:PUB00100168],[cite:PUB00100167]]. TMEM106B localises to late endosomes and lysosomes, and it is involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6 [[cite:PUB00070924]]. Its overexpression is associated with familial frontotemporal lobar degeneration [[cite:PUB00100169]]. It has also been identified as a protein required for productive SARS-CoV-2 [[cite:PUB00100166]]. Structural analysis of LEA-2 domains revealed that they have a long, conserved lipid-binding groove, implying that TMEM106B and its homologues Vac7 and Tag1 from yeast, may all be lipid transfer  proteins in the lumen of late endocytic organelles [[cite:PUB00100166]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100167":{"PMID":29131025,"ISBN":null,"volume":"42","issue":"5","year":2017,"title":"TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer.","URL":null,"raw_pages":"853-864","medline_journal":"Kidney Blood Press Res","ISO_journal":"Kidney Blood Press Res","authors":["Wu C","Xu J","Wang H","Zhang J","Zhong J","Zou X","Chen Y","Yang G","Zhong Y","Lai D","Li X","Tang A."],"DOI_URL":null},"PUB00100166":{"PMID":34347309,"ISBN":null,"volume":"90","issue":"1","year":2022,"title":"TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.","URL":null,"raw_pages":"164-175","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Levine TP."],"DOI_URL":null},"PUB00070924":{"PMID":24357581,"ISBN":null,"volume":"33","issue":"5","year":2014,"title":"The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.","URL":null,"raw_pages":"450-67","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Schwenk BM","Lang CM","Hogl S","Tahirovic S","Orozco D","Rentzsch K","Lichtenthaler SF","Hoogenraad CC","Capell A","Haass C","Edbauer D."],"DOI_URL":"http://dx.doi.org/10.1002/embj.201385857"},"PUB00100168":{"PMID":30456879,"ISBN":null,"volume":null,"issue":null,"year":2018,"title":"TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells.","URL":null,"raw_pages":null,"medline_journal":"J Cell Biochem","ISO_journal":"J Cell Biochem","authors":["Liu J","Zhu H."],"DOI_URL":null},"PUB00100169":{"PMID":23136129,"ISBN":null,"volume":"22","issue":"4","year":2013,"title":"The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.","URL":null,"raw_pages":"685-95","medline_journal":"Hum Mol Genet","ISO_journal":"Hum Mol Genet","authors":["Brady OA","Zheng Y","Murphy K","Huang M","Hu F."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":3111,"pathways":0,"proteins":3105,"proteomes":905,"sets":0,"structural_models":{"alphafold":2906,"bfvd":0},"structures":16,"taxa":2884},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":2380},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}