{"metadata":{"accession":"PF20997","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048305","hierarchy":null,"name":{"name":"Protein of unknown function (DUF3195) C-terminal domain","short":"DUF3195_C"},"description":[{"text":"<p>This archaeal family of proteins has no known function. This entry represents the C-terminal THUMP-like domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00037525":{"PMID":16111437,"ISBN":null,"volume":"3","issue":"9","year":2005,"title":"The genomics of disulfide bonding and protein stabilization in thermophiles.","URL":null,"raw_pages":"e309","medline_journal":"PLoS Biol","ISO_journal":"PLoS Biol.","authors":["Beeby M","O'Connor BD","Ryttersgaard C","Boutz DR","Perry LJ","Yeates TO."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pbio.0030309"}},"set_info":{"accession":"CL0747","name":"THUMP"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":4,"pathways":0,"proteins":4,"proteomes":4,"sets":1,"structural_models":{"alphafold":4},"structures":1,"taxa":17},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":2},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}