{"metadata":{"accession":"PF20935","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR047741","hierarchy":null,"name":{"name":"Family of unknown function (DUF6847)","short":"DUF6847"},"description":[{"text":"<p>This family represents bacterial uncharacterised proteins such as Uncharacterized conserved protein Dip1984 from Corynebacterium diphtheriae, which shows an all-alpha structure. Some members of this family are annotated as septicolysin, such as [swissprot:H6NMB2], a cholesterol-dependent pore-forming cytolysin that acts to facilitate the infection of certain pathogenic gram-positive bacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1092,"pathways":0,"proteins":1085,"proteomes":1032,"sets":0,"structural_models":{"alphafold":694},"structures":1,"taxa":1824},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":232,"alignment:full":542},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}