"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF20925"	"{'subfamilies': 0, 'domain_architectures': 65, 'interactions': 0, 'matches': 1857, 'pathways': 0, 'proteins': 1838, 'proteomes': 802, 'sets': 1, 'structural_models': {'alphafold': 89, 'bfvd': 0}, 'structures': 12, 'taxa': 2997}"	"{}"	"[{'text': ""<p>HTT is expressed in many tissues, with various expression levels and is involved in a number of cellular functions. However, its exact function is not yet clear. An an abnormal polyglutamine (polyQ) expansion in this protein causes Huntington's disease (HD) a progressive autosomal-dominant neurodegenerative disease characterised by an uncontrolled motor movement known as chorea, cognitive disorder and depression [[cite:PUB00100583]]. HTT consists of multiple HEAT repeats organised in N-terminal, bridge (represented in this entry) and C-terminal domains [[cite:PUB00100583]], which function as a scaffold that mediates interactions with binding partners. This domain connects the N- and C-HEAT domains.</p>"", 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR048412"	False	False	False	"{'PUB00100584': {'PMID': 32668197, 'ISBN': None, 'volume': '28', 'issue': '9', 'year': 2020, 'title': 'The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.', 'URL': None, 'raw_pages': '1035-1050.e8', 'medline_journal': 'Structure', 'ISO_journal': 'Structure', 'authors': ['Jung T', 'Shin B', 'Tamo G', 'Kim H', 'Vijayvargia R', 'Leitner A', 'Marcaida MJ', 'Astorga-Wells J', 'Jung R', 'Aebersold R', 'Peraro MD', 'Hebert H', 'Seong IS', 'Song JJ.'], 'DOI_URL': None}, 'PUB00100583': {'PMID': 29466333, 'ISBN': None, 'volume': '555', 'issue': '7694', 'year': 2018, 'title': 'The cryo-electron microscopy structure of huntingtin.', 'URL': None, 'raw_pages': '117-120', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Guo Q', 'Bin Huang', 'Cheng J', 'Seefelder M', 'Engler T', 'Pfeifer G', 'Oeckl P', 'Otto M', 'Moser F', 'Maurer M', 'Pautsch A', 'Baumeister W', 'Fernandez-Busnadiego R', 'Kochanek S.'], 'DOI_URL': None}}"	""	"{'name': 'Huntingtin, bridge', 'short': 'Htt_bridge'}"	""	""	"{'accession': 'CL0020', 'name': 'TPR'}"	"pfam"	"repeat"	""