This presumed domain is functionally uncharacterised and it is found in bacterial (predominantly in cyanobacteria) and eukaryotic (mainly from plants) sequences. Structure prediction using AlphaFold resource, suggest that this domain may have a START-like (StAR-related lipid-transfer) fold consisting of an alpha/beta structure of a helix-grip fold, that forms cavities for hydrophobic substrates or ligands which may indicate a possible function for this domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0209","name":"Bet_v_1_like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":469,"pathways":0,"proteins":466,"proteomes":305,"sets":1,"structural_models":{"alphafold":343},"structures":0,"taxa":879},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":386},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}