This domain, mainly found in bacteria and eukaryotes, is functionally uncharacterised. This domain is approximately 100 amino acids in length and, based on structure prediction and overlaps with other families, belongs to the transthyretin superfamily. It is likely to have a seven stranded beta sandwich fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0287","name":"Transthyretin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":408,"pathways":0,"proteins":408,"proteomes":223,"sets":1,"structural_models":{"alphafold":195},"structures":0,"taxa":427},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":72,"alignment:full":137},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}