This family of proteins is functionally uncharacterised. This family of proteins is mainly found in bacteria and archaea. Proteins in this family are around 100 amino acids in length. There are two conserved sequence motifs, CGxxxCxC containing three conserved Cys residues and HGP. AlphaFold3 predicts a confident homodimer for A0A133VII6 (ipTM=0.82 pTM=0.83). These proteins have a positively charged surface patch and some members appear likely to bind DNA according to AlphaFold 3 predictions. This family is related to [pfam:PF07913].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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