{"metadata":{"accession":"PF20416","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046523","hierarchy":null,"name":{"name":"U3 small nucleolar RNA-associated protein 20 domain","short":"UTP20"},"description":[{"text":"<p>This domain is found towards the C-terminal the U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and its human homologue, also known as DRIM (Down-Regulated In Metastasis). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [[cite:PUB00014724]]. Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [[cite:PUB00014725],[cite:PUB00101284]]. UTP20 is a huge alpha-solenoid that functions as a scaffold [[cite:PUB00101286],[cite:PUB00101285]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101285":{"PMID":32943522,"ISBN":null,"volume":"369","issue":"6510","year":2020,"title":"Cryo-EM structure of 90<i>S</i> small ribosomal subunit precursors in transition states.","URL":null,"raw_pages":"1477-1481","medline_journal":"Science","ISO_journal":"Science","authors":["Du Y","An W","Zhu X","Sun Q","Qi J","Ye K."],"DOI_URL":null},"PUB00014724":{"PMID":9673349,"ISBN":null,"volume":"18","issue":"3A","year":1998,"title":"Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis.","URL":null,"raw_pages":"1409-21","medline_journal":"Anticancer Res","ISO_journal":"Anticancer Res.","authors":["Schwirzke M","Gnirke A","Bork P","Tarin D","Weidle UH."],"DOI_URL":null},"PUB00101284":{"PMID":17498821,"ISBN":null,"volume":"1773","issue":"6","year":2007,"title":"Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.","URL":null,"raw_pages":"863-8","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim Biophys Acta","authors":["Wang Y","Liu J","Zhao H","Lu W","Zhao J","Yang L","Li N","Du X","Ke Y."],"DOI_URL":null},"PUB00101286":{"PMID":31378463,"ISBN":null,"volume":"75","issue":"6","year":2019,"title":"Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.","URL":null,"raw_pages":"1256-1269.e7","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Cheng J","Baßler J","Fischer P","Lau B","Kellner N","Kunze R","Griesel S","Kallas M","Berninghausen O","Strauss D","Beckmann R","Hurt E."],"DOI_URL":null},"PUB00014725":{"PMID":12837249,"ISBN":null,"volume":"113","issue":"7","year":2003,"title":"A panoramic view of yeast noncoding RNA processing.","URL":null,"raw_pages":"919-33","medline_journal":"Cell","ISO_journal":"Cell","authors":["Peng WT","Robinson MD","Mnaimneh S","Krogan NJ","Cagney G","Morris Q","Davierwala AP","Grigull J","Yang X","Zhang W","Mitsakakis N","Ryan OW","Datta N","Jojic V","Pal C","Canadien V","Richards D","Beattie B","Wu LF","Altschuler SJ","Roweis S","Frey BJ","Emili A","Greenblatt JF","Hughes TR."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(03)00466-5"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":77,"interactions":0,"matches":3767,"pathways":0,"proteins":3725,"proteomes":3019,"sets":1,"structural_models":{"alphafold":200},"structures":41,"taxa":8023},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":2865},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}