{"metadata":{"accession":"PF20410","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046519","hierarchy":null,"name":{"name":"X-Tfes, XVIPCD","short":"X-Tfes_XVIPCD"},"description":[{"text":"<p>This conserved domain is found in Xanthomonas VirD4 interacting proteins (XVIPs) and other type IV secretion system (T4SS) specialised in translocating effector proteins (toxic effector proteins, X-Tfes) into competing gram-negative species, leading to target cell death. This domain interacts with the central all-alpha domain of VirD4. Its structure shows two well ordered N-terminal antiparallel alpha-helices that pack against a carboxyl-terminal three-stranded antiparallel beta sheet [[cite:PUB00151936],[cite:PUB00145392],[cite:PUB00151937]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151936":{"PMID":15774874,"ISBN":null,"volume":"187","issue":"7","year":2005,"title":"Identification of new protein-protein interactions involving the products of the chromosome- and plasmid-encoded type IV secretion loci of the phytopathogen Xanthomonas axonopodis pv. citri.","URL":null,"raw_pages":"2315-25","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Alegria MC","Souza DP","Andrade MO","Docena C","Khater L","Ramos CH","da Silva AC","Farah CS."],"DOI_URL":"https://doi.org/10.1128/JB.187.7.2315-2325.2005"},"PUB00151937":{"PMID":34983846,"ISBN":null,"volume":"119","issue":"1","year":2022,"title":"Structural basis for effector recognition by an antibacterial type IV secretion system.","URL":null,"raw_pages":"e2112529119","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Oka GU","Souza DP","Cenens W","Matsuyama BY","Cardoso MVC","Oliveira LC","da Silva Lima F","Cuccovia IM","Guzzo CR","Salinas RK","Farah CS."],"DOI_URL":"https://doi.org/10.1073/pnas.2112529119"},"PUB00145392":{"PMID":25743609,"ISBN":null,"volume":"6","issue":null,"year":2015,"title":"Bacterial killing via a type IV secretion system.","URL":null,"raw_pages":"6453","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Souza DP","Oka GU","Alvarez-Martinez CE","Bisson-Filho AW","Dunger G","Hobeika L","Cavalcante NS","Alegria MC","Barbosa LR","Salinas RK","Guzzo CR","Farah CS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":1263,"pathways":0,"proteins":1260,"proteomes":153,"sets":0,"structural_models":{"alphafold":571},"structures":2,"taxa":231},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":309},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}