{"metadata":{"accession":"PF20238","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046530","hierarchy":null,"name":{"name":"Copper acquisition factor BIM1-like","short":"BIM1-like_dom"},"description":[{"text":"<p>This domain is found in fungal proteins, including copper acquisition factor BIM1 from Cryptococcus neoformans, a cell-surface bound protein that functions in the copper-accumulation pathway shared by the CUF1-dependent copper transporter CTR1 [[cite:PUB00101283],[cite:PUB00101282]]. BIM1 facilitates copper acquisition in the brain of mammalian hosts and acts as a copper-dependent virulence trait in fungal meningitis [[cite:PUB00101283]]. This domain has a lytic polysaccharide monooxygenase-like (LPMO, [pfam:PF03067]) fold,  which are evolutionarily related but have diverged to a different biological function.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101282":{"PMID":31932718,"ISBN":null,"volume":"16","issue":"3","year":2020,"title":"A fungal family of lytic polysaccharide monooxygenase-like copper proteins.","URL":null,"raw_pages":"345-350","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Labourel A","Frandsen KEH","Zhang F","Brouilly N","Grisel S","Haon M","Ciano L","Ropartz D","Fanuel M","Martin F","Navarro D","Rosso MN","Tandrup T","Bissaro B","Johansen KS","Zerva A","Walton PH","Henrissat B","Leggio LL","Berrin JG."],"DOI_URL":null},"PUB00101283":{"PMID":31932719,"ISBN":null,"volume":"16","issue":"3","year":2020,"title":"A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis.","URL":null,"raw_pages":"337-344","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Garcia-Santamarina S","Probst C","Festa RA","Ding C","Smith AD","Conklin SE","Brander S","Kinch LN","Grishin NV","Franz KJ","Riggs-Gelasco P","Lo Leggio L","Johansen KS","Thiele DJ."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":4180,"pathways":0,"proteins":4158,"proteomes":1330,"sets":1,"structural_models":{"alphafold":3468},"structures":3,"taxa":2901},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":92,"alignment:full":3329},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6ibh","name":"Copper binding protein from Laetisaria arvalis (LaX325)"}}}