{"metadata":{"accession":"PF20216","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046483","hierarchy":null,"name":{"name":"Family of unknown function (DUF6576)","short":"DUF6576"},"description":[{"text":"<p>This presumed domain is functionally uncharacterised. This domain family corresponds to the C-terminal domain of proteins that are thought to belong to the rhomboid family. It is approximately 40 amino acids in length and it is found mainly in Bacteroidetes. It contains the conserved sequences DxILDKI, GYxxL and EKxxL.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":2544,"pathways":0,"proteins":2544,"proteomes":2355,"sets":0,"structural_models":{"alphafold":1724},"structures":0,"taxa":3320},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":1299},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}