This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 107 and 214 amino acids in length. These proteins may have a threefold symmetric beta-trefoil fold, a symmetric protein structure thought to be conserved in protein evolution [[cite:PUB00101220]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00101220":{"PMID":21173271,"ISBN":null,"volume":"108","issue":"1","year":2011,"title":"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.","URL":null,"raw_pages":"126-30","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Lee J","Blaber M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":351,"pathways":0,"proteins":351,"proteomes":310,"sets":0,"structural_models":{"alphafold":197},"structures":0,"taxa":720},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":143},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}