{"metadata":{"accession":"PF20178","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046673","hierarchy":null,"name":{"name":"Dermonecrotic toxin, N-terminal domain","short":"ToxA_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of bacterial proteins, such as the dermonecreotic toxin (ToxA) from Pasteurella multocida, an osteolytic toxin that induces bone resorption. It is a potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis a major respiratory disease in pigs. This domain contributes to the membrane localisation of its C-terminal domains [[cite:PUB00040389]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00040389":{"PMID":17360394,"ISBN":null,"volume":"104","issue":"12","year":2007,"title":"Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin.","URL":null,"raw_pages":"5139-44","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Kitadokoro K","Kamitani S","Miyazawa M","Hanajima-Ozawa M","Fukui A","Miyake M","Horiguchi Y."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0608197104"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":67,"interactions":0,"matches":3160,"pathways":0,"proteins":2773,"proteomes":355,"sets":0,"structural_models":{"alphafold":314},"structures":2,"taxa":512},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":84,"alignment:full":320},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}