{"metadata":{"accession":"PF20126","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045397","hierarchy":null,"name":{"name":"Toxin TumE","short":"TumE"},"description":[{"text":"<p>This entry represents a family of proteins found in archaea and bacteria. These proteins have been recently described as the toxin component TumE from the novel toxin-antitoxin system TumA, which constitutes a translation-targeting toxic effector [[cite:PUB00154744]]. These proteins are predicted to adopt a conserved alpha+beta fold, where two alpha-helices pack against an antiparallel beta-sheet with seven strands [[cite:PUB00154744]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00154744":{"PMID":37704037,"ISBN":null,"volume":"622","issue":"7983","year":2023,"title":"Uncovering new families and folds in the natural protein universe.","URL":null,"raw_pages":"646-653","medline_journal":"Nature","ISO_journal":"Nature","authors":["Durairaj J","Waterhouse AM","Mets T","Brodiazhenko T","Abdullah M","Studer G","Tauriello G","Akdel M","Andreeva A","Bateman A","Tenson T","Hauryliuk V","Schwede T","Pereira J."],"DOI_URL":"https://doi.org/10.1038/s41586-023-06622-3"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1963,"pathways":0,"proteins":1963,"proteomes":1095,"sets":0,"structural_models":{"alphafold":1558},"structures":0,"taxa":2207},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":119,"alignment:full":969},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}