This domain of unknown function is found in uncharacterised proteins from Proteobacteria. This domain is approximately 80 amino acids in length and exhibits overlaps with [pfam:PF04717], which suggests that it has an OB fold and, thus, it belongs to the same clan. Many proteins containing this domain are related to the Type VI secretion system and to Phage-related baseplate proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098812":{"PMID":26894532,"ISBN":null,"volume":"72","issue":"Pt 1","year":2016,"title":"Lattice filter for processing image data of three-dimensional protein nanocrystals.","URL":null,"raw_pages":"34-9","medline_journal":"Acta Crystallogr D Struct Biol","ISO_journal":"Acta Crystallogr D Struct Biol","authors":["van Genderen E","Li YW","Nederlof I","Abrahams JP."],"DOI_URL":null}},"set_info":{"accession":"CL0021","name":"OB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":419,"pathways":0,"proteins":419,"proteomes":347,"sets":1,"structural_models":{"alphafold":254},"structures":0,"taxa":625},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":78,"alignment:full":191},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}