This presumed domain is functionally uncharacterised. This domain family is found in plants, and is approximately 120 amino acids in length. It is found in hypothetical UvrD-like Helicases and related sequences, all containing a P-loop motif that is characteristic of the AAA superfamily. This domain is located towards the N-terminal, adjacent the AAA domain ([pfam:PF13086]). There are two conserved motifs, GD and RIW. There is also a highly conserved D residue.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":147,"interactions":0,"matches":3291,"pathways":0,"proteins":3111,"proteomes":374,"sets":0,"structural_models":{"alphafold":1547},"structures":0,"taxa":1059},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":2078},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}