{"metadata":{"accession":"PF20049","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045609","hierarchy":null,"name":{"name":"Domain of unknown function (DUF6451)","short":"DUF6451"},"description":[{"text":"<p>This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, predominantly in Platyhelminthes, and is approximately 40 amino acids in length. It contains the conserved sequences QLxNIWNSK and KxRIFN. Many sequences containing this domain also contain a reverse transcriptase domain ([pfam:PF00078]).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0027","name":"RdRP"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":141,"interactions":0,"matches":2694,"pathways":0,"proteins":2654,"proteomes":93,"sets":1,"structural_models":{"alphafold":2509},"structures":0,"taxa":536},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":2337},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}