{"metadata":{"accession":"PF20044","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045616","hierarchy":null,"name":{"name":"Family of unknown function (DUF6446)","short":"DUF6446"},"description":[{"text":"<p>This family of proteins is functionally uncharacterised. This family of proteins is predominantly found in Rhodobacterales. Proteins in this family are typically between 160 and 175 amino acids in length. There are some conserved motifs: IDA/S, SSPxRxRACF and DG. Many members in this family are thought to be histidine kinases.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":596,"pathways":0,"proteins":592,"proteomes":592,"sets":0,"structural_models":{"alphafold":444},"structures":0,"taxa":829},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":154,"alignment:full":422},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}