This presumed domain is functionally uncharacterised. This domain family is predominantly found in Bacteroidetes, and is about 100 amino acids in length. This domain contains a highly conserved YDxxGR motif which suggests that it is related the RHS repeats, that appear to be involved in ligand binding. RHS repeats share structural similarity with the eukaryotic tyrosine-aspartate (YD) repeat [[cite:PUB00070343]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00070343":{"PMID":23913273,"ISBN":null,"volume":"501","issue":"7468","year":2013,"title":"The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device.","URL":null,"raw_pages":"547-50","medline_journal":"Nature","ISO_journal":"Nature","authors":["Busby JN","Panjikar S","Landsberg MJ","Hurst MR","Lott JS."],"DOI_URL":"http://dx.doi.org/10.1038/nature12465"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":258,"interactions":0,"matches":2128,"pathways":0,"proteins":2105,"proteomes":812,"sets":0,"structural_models":{"alphafold":752},"structures":0,"taxa":1303},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":259,"alignment:full":975},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}