{"metadata":{"accession":"PF20033","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045497","hierarchy":null,"name":{"name":"Domain of unknown function (DUF6438)","short":"DUF6438"},"description":[{"text":"<p>This domain of unknown function is found in uncharacterised proteins from bacteria and archaea. This domain is about 75 amino acids in length and it contains the conserved motif CxxxGxCP. Towards the C-terminal there are two conserved residues, a Glycine and an Aspartate. Some of the proteins containing this domain also have an ankyrin repeat-containing region. This domain is related to the Emfourin proteins [pfam:PF20242] and may have a related peptidase inhibitor function.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":1103,"pathways":0,"proteins":1102,"proteomes":934,"sets":0,"structural_models":{"alphafold":697},"structures":0,"taxa":1497},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":141,"alignment:full":484},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}