This domain of unknown function is found in uncharacterised bacterial proteins. This domain is about 60 amino acids in length and contains the conserved motifs GPY, GxxC and GCxC. These conserved cysteine residues and the fact that this domain has overlaps with families in clan CL0172 suggest that it is related to thioredoxins and it is likely in thiol-disulfide isomerases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0172","name":"Thioredoxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":805,"pathways":0,"proteins":805,"proteomes":760,"sets":1,"structural_models":{"alphafold":452},"structures":0,"taxa":1020},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":63,"alignment:full":266},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}