This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001396) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the aldgamycin J biosynthetic gene cluster from Streptomyces sp. A1(2016) [[cite:PUB00099444]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099444":{"PMID":27191535,"ISBN":null,"volume":"17","issue":"13","year":2016,"title":"A Single Gene Cluster for Chalcomycins and Aldgamycins: Genetic Basis for Bifurcation of Their Biosynthesis.","URL":null,"raw_pages":"1241-9","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Tang XL","Dai P","Gao H","Wang CX","Chen GD","Hong K","Hu D","Yao XS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":17,"pathways":0,"proteins":17,"proteomes":17,"sets":0,"structural_models":{"alphafold":5},"structures":0,"taxa":57},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":7},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}